At the end of the regular season in June, he faced off against former UFC lightweight champion Stevie Ray for the last time in the PFL. To make the playoffs, Pettis (25-13) prioritized avoiding injury versus Ray after earning six points with a first-round victory in his season debut. Pettis believes this strategy was a contributing reason in Ray's submission defeat. Pettis and Ray won the first round of their boxing match. On August 5 in the 2022 PFL playoff semifinals, Pettis will be back in action.